Studies with Hydroxyurea VII. Hydroxyurea and the Synthesis of Functional Proteins
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چکیده
منابع مشابه
Hydroxyurea-induced inhibition of deoxyribonucleotide synthesis: studies in intact cells.
Hydroxyurea-induced inhibition of thymidine incorporation by monolayers of HeLa celLswas partially prevented and reversed by addition of deoxyadenosine, deoxyguanosine, and deoxycytidine to the culture medium. All 3 deoxyribonucleosides were required for optimal effect. Hydroxyurea inhibited incorjwration of thymidine into DNA of embryos of the sand-dollar species Echinarachnius parma. The onse...
متن کاملHydroxyurea-induced Inhibition of Deoxyribonucleotide Synthesis: Studies in Intact Cells1
Hydroxyurea-induced inhibition of thymidine incorporation by monolayers of HeLa celLswas partially prevented and reversed by addition of deoxyadenosine, deoxyguanosine, and deoxycytidine to the culture medium. All 3 deoxyribonucleosides were required for optimal effect. Hydroxyurea inhibited incorjwration of thymidine into DNA of embryos of the sand-dollar species Echinarachnius parma. The onse...
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Introduction: The β-thalassaemias represent a heterogenous group of diseases resulting from decreased β-globin mRNA expression and imbalanced alpha/betaglobin chain synthesis which are clinically manifested by ineffective erythropoiesis and excessive hemolysis. Increasing levels of hemoglobin F (HbF) by improving the balance in globin chain synthesis. Hydroxyurea (HU), as an effective with lo...
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Hydroxyurea (HU) has been successfully used in patients with β-thalassemia intermedia (β-TI). We aimed to evaluate the effect of the long-term use of HU on thyroid function in patients with β-TI. Seventy-five patients with β-TI aged≥11 years and taking HU were randomly selected during 2010 in southern Iran. Thirty-one patients with β-TI without HU were considered as a control group. Serum level...
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100 Hydroxyurea, which is an inhibitor of ribonucleoside reductase and is used as a systemic antitumor agent, is frequently used for the treatment of myeloproliferative and hematologic diseases. While the most common side effect is myelosuppression, gastrointestinal symptoms such as nausea, vomiting, stomatitis, and anorexia and rash, skin ulcers, hyperpigmentation in nails, and dermatologic to...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1967
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.94.4.1025-1033.1967